Matteo Iannacone, MD, PhD

Director, Division of Immunology, Transplantation, and Infectious Diseases
Professor of Pathology
Head, Dynamics of Immune Responses
San Raffaele Scientific Institute & University
Via Olgettina, 58 – 20132 Milano, ITALY
+39 (348) 853-3711 • iannacone.matteo@hsr.it •
www.iannaconelab.com • Twitter: @iannaconelab
Married, two children (born 2013 and 2016)

ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Researcher ID: I-8507-2018
Google Scholar: https://scholar.google.it/citations?user=b3B6baUAAAAJ&hl=en

EDUCATION:

2011 Ph.D. in Immunology, Vita-Salute San Raffaele University, Milan (IT)

2007 European Board Certification in Internal Medicine

2001 M.D. degree, University of Milan (IT)

POSITIONS AND TRAINING:

2023 – present Director, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Milan (IT)

2020 – present Associate Professor of Pathology, Vita-Salute San Raffaele University, Milan (IT)

2010 – present Group Leader, San Raffaele Scientific Institute, Milan (IT)

2007 – 2010 Postdoctoral Fellow, Harvard Medical School, Boston, MA
(Advisor: Uli von Andrian)

2002 – 2006 Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (Advisors: Luca Guidotti and Frank Chisari)
2023 – present Director, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Milan (IT)

2020 – present Associate Professor of Pathology, Vita-Salute San Raffaele University, Milan (IT)

2010 – present Group Leader, San Raffaele Scientific Institute, Milan (IT)

2007 – 2010 Postdoctoral Fellow, Harvard Medical School, Boston, MA
(Advisor: Uli von Andrian)

2002 – 2006 Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (Advisors: Luca Guidotti and Frank Chisari)

HONORS AND AWARDS:

2024 ERC Advanced Grant
2024 “Alessandro Moretta - Ambasciatori della Ricerca” Prize from Il Cenacolo delle Scienze e della Cultura
2023 ERC Proof of Concept Grant
2021 Elected EMBO Member
2020 Elected Member of the Henry Kunkel Society
2020 ERC panel member for Starting Grants LS6 “Immunity, Infection and Immunotherapy”
2020 ERC Proof of Concept Grant
2017 Chiara D’Onofrio Award
2016 ERC Consolidator Grant
2016 EMBO Young Investigator Award
2015 European Association for the Study of the Liver (EASL) Emerging Leader Award
2011 ERC Starting Grant
2010 Armenise-Harvard Foundation Career Development Award
2008 Armenise-Harvard Foundation Postdoctoral Fellowship

PROFESSIONAL ACTIVITIES:

Journal Reviewer: Nature, Science, Cell, Immunity, Nature Immunology, Nature Medicine, Nature Biotechnology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gut, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology, Heliyon, Mucosal Immunology

Grant Reviewer: European Research Council (ERC), UK Medical Research Council (MRC), Wellcome Trust, European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), La Caixa Foundation, Israel Science Foundation, Austrian Academy of Sciences (ÖAW),Swiss National Science Foundation, Swiss Cancer League, Austrian Science Fund (FWF), Einstein Foundation Berlin, Helmholtz Association, Singapore Agency for Science, Technology & Research (A*STAR), Singapore National Medical Research Council, Canadian Institutes of Health Research, Hellenic Foundation for Research and Innovation.

Editorial Boards: Science Immunology (2019 – present), Journal of Experimental Medicine (2023 – present), EMBO Journal (2022 – present; founding member of the Catalysts program), European Journal of Immunology (Executive Committee 2022 – present; Editor-in-chief, 2025 – present), hLife (2023 – present), Genes & Immunity (2023 – present), Virology (2023 – present), Review Commons (2021 – present), Faculty Opinion (2021 – present), Current Opinion in Virology (section editor of Viral Immunity in 2015 and 2022).

Conference Organization: 1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1st EMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rd International Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); Global Immunotalks (Virtual Conference Series; 2021 – present); 4th International Workshop “Imaging the Immune System” (2021, virtual); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Saint-Malo, France (2022); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2022); EMBO Annual Young Investigator Meeting, Milan, Italy (2023); 5th EMBO Workshop “Imaging the Immune System”, Lugano, Switzerland (2023); 20th International Microscopy Congress (Live Imaging of Cells, Tissues and Organisms sessions), Busan, Korea (2023); Gordon Research Conference, Immunochemistry and Immunobiology (2024, Co-Vice Chair); 3rd EMBO Workshop “Pathogen Immunity and Signaling”, San Servolo, Venice, Italy (2024); International HBV Meeting, Chicago, USA (2024); European Congress of Virology, Cavtat/Dubrovnik, Croatia (2025, Scientific Committee Member); Cell Bio 2025 (Annual Meeting of the American Society of Cell Biology), Philadelphia, PA (2025, Program Committee Member); Gordon Research Conference, Immunochemistry and Immunobiology (2026, Co-Chair); Cell Bio 2026 (Annual Meeting of the American Society of Cell Biology), TBD (2026, Program Committee Member).

Scientific Advisory Boards: Department of Immunology, Institut Pasteur (2019); GentiBio (2023 – present)

Commissions of trust: European Research Council (ERC) Panel Member for the LS6 Starting Grants (2021 – present), ATIP-AVENIR Program (LS6 Panel Member 2018 – present; LS6 Panel Chair 2022- present), Swiss National Science Foundation Panel Member (Division Biology and Medicine, 2023 - present), Chair of the Expert Committee at HCERES for the evaluation of INSERM and CNRS units (2022 – present), MED3 Panel Member for the Research Foundation – Flanders (FWO), COVID-19 Animal Models WHO Working Group (2021 – present), Singapore National Medical Research Council (Panel Member 2018 – 2020), Italian Association of Immunologists (SIICA) Executive Committee (2020 – 2021 and 2024 – 2027); Reviewer for the Liver Immunology abstracts at EASL Congress (2023 – 2025), EMBO Installation Grants Committee (2023 – 2027).

MAJOR ADMINISTRATIVE AND INSTITUTIONAL RESPONSABILITIES:

2023 – present Director, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute
2023 – present Steering Committee, Liver Center, San Raffaele Scientific Institute
2020 – 2022 Committee for Appointment and Promotion, San Raffaele Scientific Institute
2014 – 2020 Immunology Seminar Series Organizing Committee, San Raffaele Scientific Institute
2017 – 2019 Scientific Board, PhD program in Molecular Medicine, Vita-Salute San Raffaele University
2015 – 2020 External Seminar Committee, San Raffaele Scientific Institute

TEACHING EXPERIENCE:

2020 – present Associate Professor of Pathology and Immunology, Vita-Salute San Raffaele University, Milan, Italy
2012 – 2020 Adjunct Professor of Pathology and Immunology, Vita-Salute San Raffaele University, Milan, Italy

CONSULTANTSHIPS and ADVISORY BOARDS:

Gilead Sciences, Foster City, CA
Asher Biotherapeutics, San Carlos, CA
GentiBio, Cambridge, MA
BlueJay Therapeutics, San Mateo, CA
Aligos Therapeutics, South San Francisco, CA
HumAbs Biomed/Vir Biotechnology, Bellinzona, Switzerland
BioNTech, Mainz, Germany
Excision BioTherapeutics, Watertown, MA
Moderna, Cambridge, MA

ACADEMIC SUPERVISION:

Technicians:
• Pietro Di Lucia (2010 – present)
• Marta Mainetti (2010 – present)
• Leonardo Giustini (2016 – present)
• Elisa Bono (2017 – present)
• Mattia Freschi (2019 – 2022; now product and sales specialist at Prodotti Gianni, Milan, Italy)
• Chiara Perucchini (2020 – present)
• Sara De Palma (2022 – present)
• Chiara Malpighi (2023 – 2025; now at Sibylla Biotech, Bresso, Italy)

Undergraduate students:
• Angelo Amabile (2010 – 2012; now postdoc with Brian Brown at Mount Sinai, NYC)
• Maurizio Vacca (2010 – 2013; now Scientist at Janssen)
• Gabriele Galliverti (2011 – 2013; now Medical Affairs Manager at SFL, Basel)
• Lucia Ganzer (2013 – 2015; now postdoc at CNR, Milan)
• Claudia Cristofani (2015 – 2017; now at Boehringer Ingelheim)
• Gianmaria Maganuco (2015 – 2018; now M.D. student at U Genova)
• Valeria Cutillo (2016 – 2019; now Medical Science Liaison at Amgen)
• Gioia Ambrosi (2017 – 2020; now M.S. student at U of Milano - Bicocca)
• Alessandra Fiore (2017 – 2019; now at Roche)
• Sara Raia (2018 – 2019; now predoc at San Raffaele, Milan)
• Eleonora Consolo (2018 – 2019; now at Sanofi-Pasteur)
• Federico Oberrauch (2018 – 2019; now M.S. student in Health Management)
• Federico De Ponti (2018 – 2020; now PhD student with Charlotte Scott at VIB, Leuven)
• Stefano Gilotto (2019 – 2020)
• Francesca Righetti (2020 – 2021; now predoc at IRB, Bellinzona, Switzerland)
• Alessandro Lussana (2020 – 2021; now PhD student at EMBL-EBI in Cambridge, UK)
• Giulia Nosetto (2020 – 2023; now Study Coordinator at Ospedale San Raffaele, Milano, Italy)
• Marta Mangione (2020 – 2022; now predoc at IFOM-IEO, Milan, Italy)
• Rosanna Santella (2021 – 2022)
• Anna Celant (2022 – present)
• Giuliana Furiato (2022 – present)
• Michele D’Antonio (2022 – present)
• Riccardo Musi (2023)
• Valentina Sperto (2023 – present)
• Elisa Pensieri (2024 – present)
• Alessia Manca (2024 – present)
• Fabio Tosi (2024 – present)
• Alessandro Aresu (2024 – present)
• Francesca Silini (2024 – present)

Ph.D. students:
• Donato Inverso (2011 – 2016; now Group Leader and Assistant Professor at San Raffaele Scientific Institute, Milan, Italy)
• Marco De Giovanni (2013 – 2019; now Group Leader at San Raffaele Scientific Institute, Milan, Italy)
• Giorgia De Simone (2016 – 2021; now Medical Science Liaison at Tillotts Pharma)
• Valeria Fumagalli (2017 – 2023; AIRC fellowship; now Assistant Professor at San Raffaele Scientific Institute, Milan, Italy)
• Eleonora Sala (2018 – 2023; now Project Manager at Charles River)
• Valentina Venzin (2019 – present)
• Bianca Partini (2019 – 2023; AIRC fellowship; now Study Coordinator at Ospedale San Raffaele, Milano, Ital)
• Davide Marotta (2019 – present)
• Chiara Laura (2019 – present)
• Marta Grillo (2020 – present)
• Maria Nelli (2021 – present)
• Violette Mouro (2022 – present)

Postdoctoral fellows:
• Elena Tonti (2010 – 2012; now Assistant Professor at McMaster University)
• Nereida Jimenez de Oya (2011 – 2016; now Principal Investigator at INIA-CSIC, Madrid)
• Stefano Sammicheli (2011 – 2016; now Director of Discovery Oncology at Ichnos Sciences, Lausanne)
• Laura Sironi (2012 – 2013; now Associate Professor at University of Milano – Bicocca)
• Jessica Fioravanti (2012 – 2016; Marie Curie fellowship; now Senior Scientist at Lyell Immunopharma)
• Mirela Kuka (2013 – present; now Assistant Professor and Project Leader at San Raffaele Scientific Institute and University)
• Alexandre Benechet (2015 – 2018; EMBO fellowship; now Director of Intravital Imaging, University of Lausanne)
• Diletta Magini (2016; now Project Manager at CEPI - Coalition for Epidemic Prepardeness Innovations)
• Federica Moalli (2016 – present; Marie-Curie fellowship)
• Paola Zordan (2017 – 2020; now senior postdoc at San Raffaele)
• Vito Cucchiara (2018 – 2020; now Attending Urologist at San Raffaele)
• Francesco Andreata (2018 – present; Umberto Veronesi Foundation fellowship)
• Cristian Beccaria (2018 – present; EMBO fellowship)
• Xenia Ficht (2019 – 2022; iCARE fellowship; now Staff Scientist at ETH)
• Caroline Krüger (2019 – 2022; AIRC fellowship; now Scientific Officer at Swiss National Science Foundation)
• Micol Rava’ (2019 – present)
• Elena Rodriguez Bovolenta (2020 – 2022)
• Keigo Kawashima (2021 – present; Uehara Memorial fellowship; Marie-Curie Fellowship)
• Pietro Delfino (2023 – present)
• Carlotta Tacconi (2023 – present)
• Monica Giannotta (2023 – present)
• Andrea Cugurra (2023 – present)
• Caitlin Abbott (2023 – present; Marie-Curie fellowship)
• Jordan Rixon (2023 – present)

Visiting Fellows:
• Florian Gärtner (2016; from LMU, Munich, Germany)
• Vo Thi My Hoa (2016; from GSK, Siena, Italy)
• Vendi Sinkovec (2017; from University of Rijeka, Croatia)
• Lisa Sandner (2021; from University of Vienna, Austria)
• Nishi Patel (2022; from University of Calgary, Canada)
• Johannes Siewert (2023; from University of Bonn, Germany)
• Veera Panova (2023; from University of Cambridge, UK)
• Riho Saito (2023; from University of Tokyo, Japan)
• Noam Shapira (2024; from Weizmann Institute, Israel)
• Natalia Stachura (2024; from Gdansk University, Poland)
• Irene Ruiz Garrido (2024; from CNIO, Madrid, Spain)

Junior Faculty / Staff Scientists / Facility Managers:
• Mirela Kuka – Assistant Professor and Project Leader
• Federica Moalli – Facility Manager, Intravital Microscopy
• Micol Rava’ – Facility Manager, Animal Biochemistry
• Donato Inverso – Assistant Professor and Group Leader
• Valeria Fumagalli – Assistant Professor
• Marco De Giovanni – Group Leader

SELECTED INVITED LECTURES (LAST 5 YEARS):

2025, Netherlands Cancer Institute (NKI), Amsterdam
2025, Falk Symposium: Experimental Hepatology Days, Lyon, France (keynote)
2025, University College London, UK (hosts: Mala Maini and Claudia Mauri)
2025, Institut Curie, Paris, France (hosts: Ana-Maria Lennon-Dumenil, Sebastian Amigorena and Nicolas Manel)
2024, Program in Immunology, UC San Diego, CA (host: Elina Zuniga)
2024, NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute, La Jolla, CA (host: Susan Kaech)
2024, Babraham Institute’s Distinguished Lecture Series, Cambridge, UK
2024, Champalimaud Research Symposium, Lisbon, Portugal
2024, Centre d’Immunologie de Marseille-Luminy, Marseille, France (host: Marc Bajenoff)
2024, GSK Global (host: Ennio De Gregorio)
2024, ImmuneOctoberFest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
2024, Division of Medicine and of Gastroenterology, Perelman School of Medicine, University of Pennsylvania (host: Rebecca G. Wells)
2024, 19th Armenise-Harvard Symposium, “Visualizing biology: from the nano to the macro scale”, Boston, MA
2024, The Ragon Institute of Harvard and MIT, USA (host: Facundo Batista)
2024, Summer School, Helmholtz Centre for Infection Research, Braunschweig, Germany
2024, European Association for the Study of the Liver, ILC2024, Milan, Italy
2024, Stiftung Experimentelle Biomedizin (SEB), Zurich, Switzerland
2024, Bellinzona Institutes of Science (BIOS+), Switzerland
2024, Retreat of the University of Geneva (Pathology and Immunology Department), Annecy, France (keynote)
2024, 6th International Conference of Translational Immunology, Monopoli, Italy
2024, PhD Retreat of the Italian Association of Immunologists (SIICA), Otranto, Italy
2024, ENII Summer School of Advanced Immunology, Alghero, Italy
2024, Center for Applied Medical Research, Pamplona, Spain
2024, Keystone Symposium on Myeloid Targeting Strategies, Killarney, Ireland
2024, Annual Retreat of the San Raffaele Scientific Institute, Baveno, Italy
2024, University of Rijeka, Croatia (host: Stipan Joniic)
2024, EMBO PhD Course, Heidelberg, Germany
2024, Beyond Science Initiative, 9th Annual International Conference (keynote)
2024, Istituto Nazionale di Genetica Molecolare (INGM), Milan (host: Sergio Abrignani)
2024, SIICA Advanced School of Immunology
2024, 4th Midwinter Conference, Seefeld, Austria
2023, 18th International Congress of Immunology, Cape Town, South Africa
2023, Karolinska Institutet, Stockholm, Sweden (host: Carmen Gerlach)
2023, 10th European Seminars in Virology (EUSEV), Bertinoro, Italy (keynote)
2023, 8th PhD Conference in Immunology, Czechia (keynote speaker)
2023, International HBV Meeting, Kobe, Japan
2023, The Catholic University of Korea, Seoul, Korea (host: In-Beom Kim)
2023, IMMOX23 – Immunology across time and space, Oxford, UK
2023, EMBO Workshop “Imaging the Immune System”, Lugano, Switzerland
2023, European Association for the study of the Liver (EASL) Congress 2023, Vienna, Austria
2023, Keystone Symposium on B cell biology in the context of infectious diseases, autoimmunity and B cell cancers, Keystone, CO (declined for conflicting schedule)
2023, Division of Medicine and of Gastroenterology, Perelman School of Medicine, University of Pennsylvania (host: Rebecca G. Wells)
2023, 8th European Congress of Virology, Gdańsk, Poland
2023, AASLD HBV Special Interest Group Webinar on “Immune Tolerance in Chronic Hepatitis B: Mechanisms, Management and Controversies”
2023, Department of Immunology, Institut Pasteur, Paris, France (host: Pierre Bruhns)
2023, Symposium in Immunothrombosis, Munich, Germany
2023, Multimodal imaging in life sciences and cancer research, Lausanne, Switzerland
2022, Dutch Society for Immunology Annual Meeting, Leeuwenhorst (keynote)
2022, Cluster Science Days 2022 Bonn, Germany (keynote)
2022, FEBS-IUBMBM-ENABLE conference (The perfect tandem: how technology expands the frontiers of biomedicine), Sevilla, Spain (keynote)
2022, 9th European Seminars in Virology (EUSEV), Bertinoro, Italy (keynote)
2022, 6th IAAASS Innovative Approaches for Identification of Antiviral Agents, Pula (CA, Sardinia, Italy
2022, CRC 841 Symposium “Tissue inflammation”, Hamburg, Germany
2022, Immune OctoberFest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
2022, EMBO Workshop on Germinal Centers and Immune Niches (GCC 2022), Weizmann Institute of Science, Rehovot, Israel
2022, 1st Summer Symposium Systems Immunology “Network across scales”, Wurzburg, Germany
2022, 9th ANRS HBV Cure Workshop, Lyon, France
2022, Gordon Research Conference on Immunochemistry and Immunobiology, Spain
2022, EMBL in Italy 2022: Emerging approaches in human health and infectious diseases, GSK Vaccines, Siena, Italy
2022, XIII meeting of the Italian Society of Immunology (SIICA), Naples, Italy
2022, Vir Biotechnology, Bellinzona, Switzerland (host: Davide Corti)
2022, Ludwig Cancer Distinguished Seminar Series, Lausanne (host: Ping-Chih Ho)
2022, Distinguished Seminar Series, The Jackson Laboratory for Genomic Medicine, Farmington, CT
2022, Princeton University, USA (host: Alex Ploss)
2022, Portuguese Society of Immunology (SPI) annual meeting, Lisbon, Portugal
2022, King’s College, London, UK (host: Alberto Sanchez-Fueyo)
2022, Scottish Immunology Groups Network, Perth, Scotland (keynote lecture)
2022, European School of Molecular Medicine, Milan, Italy
2021, University of Salzburg, Austria (host: Iris Gratz)
2021, Argentinean Society of Immunology, Cordoba, Argentina (keynote lecture)
2021, University of Milan, Italy (PhD invited lecture)
2021, University of Massachusetts Medical School (host: Andrea Reboldi)
2021, International HBV Meeting, Toronto, Canada (keynote lecture)
2021, Austrian Association of the Molecular Life Sciences and Biotechnology annual meeting, Innsbruck, Tyrol, Austria
2021, 5th Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), Cagliari, Italy
2021, Swiss Society for Allergology and Immunology, Zurich, Switzerland
2021, French Germinal Center Symposium, Paris (keynote lecture)
2021, Oxford Imaging Symposium, UK (host: Michael Dustin)
2021, Immunology Seminar Series, Harvard Medical School, Boston, MA
2021, Global Immunotalk (hosts: Carla Rothlin and Elina Zuniga)
2021, University of Fribourg, Switzerland (host: Jens Stein)
2021, T cell connect Europe, Immunology lecture series
2020, Ludwig-Maximilians University, Munich, Germany (PhD invited lecture)
2020, Kantonsspital, St. Gallen, Switzerland (host: Burkhard Ludewig)
2020, Louis Jeantet Symposium, Geneva, Switzerland
2020, Cambridge Immunology Network, UK (host: Menna Clatworthy)
2020, Advanced School of Immunology, Italian Association of Immunologists (SIICA)
2020, ANRS “Basic and Translation Research on Hepatitis Viruses”, Paris (keynote)
2020, Keystone Symposium on Tissue Immunity, Boulder, CO
2019, Institut Curie, Paris, France (host: Nicolas Manel)
2019, The Convergence of Hematology and Immunology (CHI), Tianjin, China
2019, Armenise-Harvard Lecture, Harvard Medical School, Boston
2019, Icahn School of Medicine at Mount Sinai, NYC (hosts: Brian Brown, Miriam Merad)
2019, Tri-Institutional Seminar, New York City (hosts: Andrea Schietinger, Gabriel Victora)
2019, International Congress of Immunology, Beijing
2019, Peter Doherty Institute, Melbourne (host: Scott Mueller)
2019, Joint German-Italian Immunological Society meeting, Munich
2019, Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland
2019, EMBO Young Scientist Forum, Prague, Czech Republic
2019, Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute
2019, TRON, Mainz, Germany (host: Ugur Sahin)
2019, Tissue Immunity Symposium with a Focus on T cells, Lisbon, Portugal
2019, CeMM, Vienna, Austria (host: Sylvia Knapp)
2019, EASL International Liver Congress, Vienna, Austria
2019, EMBO Gold Medalists Meeting, Singapore
2019, Department of Pathology, UCSF (host: Max Krummel)
2019, Gilead Sciences, Foster City, CA (host: Sarah Gilmore)
2019, Stanford University, CA (host: Maria Grazia Roncarolo)
2019, IRBM Science Park, Roma (host: Carlo Toniatti)
2019, Harald von Boehmer Midwinter Conference, Seefeld, Austria
2018, Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)
2018, Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada
2018, World Congress on Microcirculation, Vancouver, Canada
2018, 5th European Congress of Immunology, Amsterdam
2018, SIICA Advanced School in Immunology, Messina, Italy
2018, European Institute of Oncology, Milan, Italy (host: Luigi Nezi)
2018, Oxford University, UK (host: Jan Rehwinkel)
2018, Cambridge University, UK (host: Milka Sarris)
2018, 44th Portuguese Society for Immunology Meeting, Lisbon, Portugal
2018, Gordon Research Conference on Immunochemistry and Immunobiology, VT
2018, Gordon Research Conference on Chemotactic Cytokines, Newry, ME
2018, TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg
2018, DKFZ, Heidelberg (host: Hellmut Augustin)
2018, 33rd Congress of the International Society for Advancement of Cytometry, Prague
2018, The Crick Institute, London, UK (host: Caetano Reis e Sousa)
2018, William Harvey Research Institute, London UK (host: Sussan Nourshargh)
2018, University of Bern, Switzerland (host: Jens Stein)
2018, University of Perugia, Italy (host: Francesca Fallarino)
2018, Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany
2018, 27th Cytomeet (Keynote Lecture), Bern, Switzerland
2018, Institute for Immunology, Munich, Germany (host: Thomas Brocker)

PATENTS

1. Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences

2. Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences

3. Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences

4. Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences

5. Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences

6. Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent 10,188,733

7. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427

8. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020/016434 – sold to Antios Therapeutics

9. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781 – sold to Antios Therapeutics

10. De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/234483

11. Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Agents and methods for treating viral infections, PCT/EP2020/064933

12. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus. WO2020/030781

13. Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Spirocyclic inhibitors of hepatitis B virus. WO2021/160617

14. Iannacone M, Guidotti LG. Agents and methods for increasing liver immune response. UK Patent Application 2018657.3

PUBLICATIONS

1. Pizzagalli DU, …, Iannacone M, … Gonzalez SF (2024) IMMUNEMAP, an open atlas of immune cell motility. Submitted

2. Altenburger LM, Claudino Carvoeiro DC, Dehio P, Zhou J, Laura C, Katoch M, Krüger C, Barreto de Albuquerque J, Pfenninger P, Martinez Magdaleno J, Abe J, Mehling M, Dengjel J, Iannacone M, Gheinani H, Stein JV (2024) A lymphoid tissue chemokine checkpoint safeguards effector CD8+ T cell differentiation. Submitted

3. Sala E, Laura C, Nelli M, Mangione M, Di Lucia P, Bono EB, Giustini L, Furiato G, Marotta D, Malpighi C, Consolo E, Beccaria CG, David E, Cohen M, Giladi A, Amit I, Guidotti LG, Iannacone M#, Kuka M# (2024) IFN- suppresses T follicular helper cell differentiation and antibody responses. Submitted (#co-last and co-corresponding authors)

4. Milani M, Starinieri F, Beretta S, Canepari C, Monti M, Zambrano S, Mazza D, Fabiano A, Simoni C, Cammarota E, Volpin M, Bortolussi G, Russo F, Biffi M, Genua M, Ostuni R, Muro AF, Montini E, Moalli F, Iannacone M, Merelli I, Cantore A (2024) Spatiotemporal liver dynamics shapes hepatocellular heterogeneity and impacts in vivo gene engineering. Submitted

5. Kawashima K, Onishi M, Kanto T, Chisari FV, Iannacone M, Suzuki Y, Tanaka Y, Isogawa M (2024) Distinct localization of cytotoxic and cytokine-producing CD8+ T cells in the liver during OX40-mediated virus inactivation. Submitted

6. Manenti S, Croese T, Finardi A, Mandelli A, Pedrini E, Marostica G, Zhong X, Waisman A, Borsellino G, Battistini L, Bacigaluppi M, Gullotta G, Moiola L, Genchi A, Iannacone M, Ostuni R, Absinta M, Schwartz M, Cassatella MA, Scapini P, Magliozzi R, Martino G, Rocca M, Furlan R (2024) Identification of PD-L2 expressing neutrophils as key regulators in CNS autoimmunity. Submitted

7. Sarker G, Chandran A, Monfeuga T, Maroteau C, Lundh S, Raimondi A, Martinez Sanchez N, Arus B, Iannacone M, Toledo EM, Domingos A (2024) The perineurium integrates leptin with its sympathetic outflow to protect against obesity. Submitted

8. Fumagalli V, Iannacone M (2024) HBV in 2024. Nature Reviews Gastroenterology & Hepatology, in press

9. De Giovanni M, Inverso D, Iannacone M (2024) Understanding local immunity to enable regionalized medicine. The EMBO Journal, in press

10. Stark K, Kilani B, Stockhausen S, Busse J, Schubert I, Tran T-D, Gaertner F, Leunig A, Pekayvaz K, Nicolai L, Fumagalli V, Stermann J, Stephan F, David C, Müller MB, Heyman B, Lux A, da Palma Guerreiro A, Frenzel LP, Schmidt CQ, Dopler A, Moser M, Chandraratne S, von Brühl M-L, Lorenz M, Korff T, Rudelius M, Popp O, Kirchner M, Mertins P, de Boer OJ, van der Wal AC, Nimmerjahn F, Iannacone M, Sperandio M, Engelmann B, Verschoor A, Massberg S (2024) Antibodies and complement are key drivers of thrombosis. Immunity, in press

11. Baldwin JG, Heuser C, Saha T, Schelker R, Slavkovic-Lukic D, Strieder N, Barden M, Mastrogiovanni F, Martin-Santos A, Raimondi A, Brohawn P, Higgs BW, Gebhar C, Kapoor V, Telford WG, Robey PG, Gautam S, Iannacone M, Inverso D, Rehli M, Fioravanti J, Sengupta S, Gattinoni L (2024) Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell, in press

12. Andreata F, Iannacone M (2024) The hidden strength of CD8+ T cells in chronic hepatitis B. Nature Immunology, 25:1515

13. Pallavicini I, Frasconi T, Catozzi C, Ceccaci E, Tiberti S, Hass D, Samson J, Heuser-Loy C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Mercurio C, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T (2024) LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness. Nature Communications, 15:7366

14. Kakogiannos N, Scalise AA, Martini E, Maderna C, Benvenuto AF, D’Antonio M, Carmignani L, Magni S, Gullotta GS, Lampugnani MG, Iannelli F, Beznoussenko GV, Mironov AA, Cerutti C, Bentley K, Philippides A, Zanardi F, Bacigaluppi M, Sigismund S, Bassani C, Farina C, Martino G, Dejana E, Iannacone M#, Inverso D#,, Giannotta M#, (2024) Gpr126 is a crucial regulator of blood-brain barrier maturation and function. Journal of Clinical Investigation, 134:e165368 (#co-last authors)

15. Venzin V, Beccaria CG, Andreata F, Fumagalli V, Iannacone M (2024) Intrahepatic immunity to hepatitis B virus. Journal of Hepatology, in press

16. Gyrd-Hansen M, Kajaste-Rudnitski A, Manel N, Rehwinkel J, van der Veen AG, Iannacone M (2024) Advancements in Pathogen Immunity and Signaling. Nature Immunology, 25:1322

17. Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Guo G, Belz L, Sobirova G, Zhang Z, Titova A, Martinez Navarro A, Pekayvaz K, Lorenz M, von Baumgarten L, Straub T, Popper B, Zheden V, Kaufmann W, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Broker T, Walzog B, Scheiermann C, Aird W,Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendrop RAJ, Iannacone M, Heinig M, Massberg S (2024) Plasmacytoid dendritic cells regulate tissue homeostasis of megakaryocytes. Nature, 631:645

18. Andreata F, Krueger CC, Laura C, Ravà M, Ficht X, Kawashima K, Beccaria CG, Moalli F, Partini B, Fumagalli V, Nosetto G, Di Lucia P, Montali I, Garcia-Manteiga JM, Bono EB, Giustini L, Perucchini C, Venzin V, Ranucci S, Inverso D, De Giovanni M, Genua M, Ostuni R, Lugli E, Isogawa M, Ferrari C, Boni C, Fisicaro P, Guidotti LG, Iannacone M (2024) Therapeutic potential of co-signaling receptor modulation in hepatitis B. Cell, 187:4078

19. HBV2023, Allweiss L, Cohen C, Dias J, Fumagalli V, Guo H, Harris JM, Hu J, Iannacone M, Isogawa M, Jeng W-J, Kim K-H, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh S-H, McKeating JA, Revill PA (2024) Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus. Journal of General Virology, 105:001978

20. Mooney AH, Draper SL, Burn OK, Andreson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab S, Painter GF, Hermans IF (2024) Preclinical evaluation of therapeutic peptide-glycolipid conjugate vaccines for chronic hepatitis B virus that stimulate antiviral activities of T cells and NKT cells. JHEP Reports, 6:101038

21. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M (2024) Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination. Nature Immunology, 25:633

22. Kawashima K, Andreata F, Beccaria CG, Iannacone M (2024) Priming and maintenance of adaptive immunity in the liver. Annual Review of Immunology, 42:375

23. Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jing J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Moalli F, Liu Z, Duan K, Narang V, Ballesteros I, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y-H, Tey HL, Chong SH, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG (2024) Deterministic reprogramming of neutrophils within tumors. Science, 383:eadf6493

24. Andreata F, Moynihan KD, Fumagalli V, Di Lucia P, Pappas DC, Kawashima K, Ni I, Bessette PH, Perucchini C, Bono E, Giustini L, Nguyen HC, Chin SM, Yeung YA, Gibbs CS, Djuretic I, Iannacone M (2024) CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus. Science Translational Medicine, 16:eadi1572

25. Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilan E, Romanenghi M, Achutti Duso B, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, De Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG (2023) The lysine demethylase LSD1 controls the balance between inflammatory and antivral responses against coronaviruses. Science Signaling, 16:eade0326

26. Haberman ER, Sarker G, Arus BA, Ziegler KA, Meunier S, Martinez-Sanchez N, Freibergerova E, Yilmaz-Özcan S, Fernandez-Gonzalez I, Zentai C, O’Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, Lopez M, Ginhoux F, Domingos AI (2023) Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis. Immunity, 57:141

27. Fumagalli V, Iannacone M (2024) The interplay of drug therapeutics and immune responses to SARS-CoV-2. Cellular and Molecular Immunology, 21:197

28. Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro E, Ng MSF, Lena MS, Drago D, Andolfo A, Mortellaro A, Corbo V, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R (2023) IL-1+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature, 623:415

29. Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Coria L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G (2023) Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine. Vaccines, 11:1546

30. Fiore A, Sala E, Laura C, Riba M, Fumagalli V, Nelli M, Mangione M, Provero P, Oberrauch F, Cristofani C, Iannacone M, Kuka M (2023) A fluorescent reporter model for the visualization and characterization of TDC. European Journal of Immunology, e2350529

31. Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N (2023) The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling. Journal of Experimental Medicine, 220:e20221466

32. Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M (2023) Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts antiviral adaptive immune responses. EMBO Molecular Medicine, 15:e17580

33. Stoler-Barak L, Harris E, Peres A, Hezroni H, Kuka M, Di Lucia P, Grenov A, Gurwicz N, Kupervaser M, Yip BH, Iannacone M, Yaari G, Crispino JD, Shulman Z (2023) B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation. Nature Communications, 14:1462

34. Gioia U, Tavella S, Martinez Orellana P, Cicio G, Colliva A, Paldino A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paladino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d’Adda di Fagagna F (2023) SARS-CoV-2 infection causes DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. Nature Cell Biology, 25:550

35. Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D (2023) Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development. Nature Immunology, 24:501

36. Epis S, Varotto-Boccazzi I, Manenti A, Rubolini D, Gabrieli P, Cattaneo GM, Gourlay L, Dapporto F, Monti M, Razzano I, Leonardi M, Iannacone M, Recordati C, Bertola L, Fiorina P, Marvasi L, Montomoli E, Zuccotti GV, Bandi C (2022) Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19. Pharmacological Research, 186:106546

37. Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Ravà M, Ryan K, Hall Y, Rayner E, Salguero J, Paterson J, Iannacone M, De Francesco R, Aurisicchio L*, Palombo F* (2022) DNA-vaccine-induced immune response correlates with lower viral SARS-CoV-2 titers in a ferret model. Vaccines, 10:1178 (*co-last authors)

38. Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Orsale MV, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R (2022) Discovery and antiviral profile of new sulfamoylbenzamide derivative as HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters, 73:128904

39. Iannacone M, Bleriot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F (2022) Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55:1141

40. Bertoletti A, Iannacone M (2022) Editorial overview: Viral pathogenesis. Current Opinion in Virology, 55:101253 (invited editorial for a section on SARS-CoV-2)

41. Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, Tufano M, Peano C, Iannacone M, Roychoudhuri R, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A (2022) Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as potential therapeutic target. Journal of Hepatology, 77:1359

42. Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Müller C*, Stein JV* (2022) Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype. Science Immunology, 7:eabf1861 (*co-last authors)

43. Iannacone M, Andreata F, Guidotti LG (2022) Immunological insights in the treatment of chronic hepatitis B. Current Opinion in Immunology, 77:102207

44. Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht M-L, Zhang Z, Kugelmann, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S (2022) Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration. Blood, 140:478

45. Iannacone M, Guidotti LG (2022) Developing a cure for chronic hepatitis B requires a fresh approach. Nature, 603:S49

46. Konjar Š*, Ficht X*, Iannacone M#, Veldhoen M# (2022) Heterogeneity of tissue resident memory T cells. Immunology Letters, 245:1 (*co-first authors; #co-last authors)

47. Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria C, David E, Maier B, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A#, Merad M#, Amit I# (2022) The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response. Nature Cancer, 3:303 (#co-last authors)

48. Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M (2022) Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability. Science Immunology, 7:eabi6112

49. Pekayvaz K, Leunig A, Kaiser R, Brambs S, Joppich M, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wiser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hölscher M, Massberg S, Stark K, Nicolai L (2022) Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Nature Communications, 13:1018

50. Aiolfi R*, Sitia G*, Iannacone M*, Brunetta I, Guidotti LG, Ruggeri ZM (2022) Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets. Science Signaling, 15:eabb0384 (*co-first authors)

51. Cossarizza A, …, Iannacone M., …, Yang J (2021) Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). European Journal of Immunology, 51:2708

52. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M (2022) Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion. Science Immunology, 7:eabl9929

53. Kuka M, Iannacone M (2022) Heterogeneity in antiviral B cell responses: lessons from the movies. Immunological Reviews, 306:224

54. Andreata F, De Simone G, Fumagalli V, Di Lucia P, Ficht X, Beccaria CG, Bleriot C, Kuka M, Ginhoux F, Iannacone M (2021) Isolation of mouse Kupffer cells for phenotypic and functional studies. STAR Protocols, 2:100831

55. Fedeli M, Kuka M, Finardi A, Albano F, Viganò V, Olson EN, Iannacone M, Furlan R, Dellabona P#, Casorati G# (2021) miR-21 sustains CD28-signaling and facilitates low affinity T-cell responses at the expense of self-tolerance. Clinical and Translational Immunology, 10:e1321 (#co-last authors)

56. Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M#, Aurisicchio L# (2021) COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19. Molecular Therapy, 29:1 (#co-last and co-corresponding authors)

57. Tuzlak S, Dejean A, Iannacone M, Quintana F, Waisman A, Ginhoux F, Korn T, Becher B (2021) Repositioning Th cell polarization from single cytokines to complex help. Nature Immunology, 22:1210

58. Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang X-M, Ang N, Shen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell E, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F (2021) Identification of two subsets of Kupffer cells with distinct functions in liver metabolism. Immunity, 54:2101

59. De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M (2021) Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. Immunity, 54:2089

60. Cilenti F, Barbiera G, Caronni N, Iodice D, Barresi S, Montaldo E, Lusito E, Miotto P, Di Lucia P, Lazarevic D, Cirillo D, Iannacone M, Genua M#, Ostuni R# (2021) A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Immunity, 54:1665 (#co-last authors)

61. Iannacone M and Guidotti LG (2022) Immunobiology and pathogenesis of hepatitis B virus infection. Nature Reviews Immunology, 22:19

62. Baudi I, Isogawa M, Moalli F, Onishi M, Kawashima K, Ito H, Ishikawa T, Wakita T, Iannacone M, Tanaka Y (2021) Type I IFN signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen. PLoS Pathogens, 17:e1009228

63. Perro M, Iannacone M, von Andrian UH, Peixoto A (2020) Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection. Virulence, 11:1640

64. Ficht X and Iannacone M (2020) Immune surveillance of the liver by T cells. Science Immunology, 5:eaba2351

65. Fumagalli V, Di Lucia P, Venzin V, Bono E, Jordan R, Frey C, Delaney W, Chisari FV, Guidotti LG, Iannacone M (2020) Antibody-mediated clearance of serum HBsAg has minimal impact on CD8+ T cell responses in mouse models of HBV pathogenesis. Journal of Experimental Medicine, 217:e20200298

66. Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV (2020) Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance. Science Immunology, 5:eaaz4371

67. De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M, Iannacone M (2020) Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization. Nature Immunology, 21:321

68. De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E (2019) CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential. Journal of Immunology, 203:3179 (*equal contribution)

69. Benechet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M (2019) Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. Nature, 574:200. Awarded with the 2019 Best Publication in Hepatology by the Italian Association for the Study of the Liver.

70. Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Nichols TC, Peters R, Iannacone M, Cantore A#, Naldini L# (2019) Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates. Science Translational Medicine, 11:eaav7325 (#co-last authors)

71. Kuka M, De Giovanni M, Iannacone M (2019) The role of type I interferons in CD4+ T cell differentiation. Immunology Letters, 215:19

72. Thierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M#, Bajenoff M# (2018) The conduit system exports locally secreted IgM from lymph nodes. Journal of Experimental Medicine, 215:2972 (#co-last authors)

73. Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E (2018) Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity. JCI Insight, 3:e122299

74. Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E (2018) Zika virus replication in dorsal root ganglia explants causes myelin degeneration. Scientific Reports, 8:10166

75. Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV (2018) The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ T cells. Journal of Experimental Medicine, 215:1869

76. Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli D (2018) Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node. Frontiers in Immunology, 9:641

77. Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G (2018) Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction and is safe and effective during acute viral infection in mouse. European Journal of Immunology, 48:1389

78. Sammicheli S, Kuka M, Iannacone M (2018) Intravital imaging of B cell responses in lymph nodes. Methods in Molecular Biology, 1763:63

79. De Giovanni M and Iannacone M (2018) In vivo imaging of adaptive immune responses to viruses. Current Opinion in Virology, 28:102

80. Kuka M and Iannacone M (2018) Viral subversion of B cell responses within secondary lymphoid organs. Nature Reviews Immunology, 18:255

81. Medaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M#, Shulman Z#, Amit I# (2017) Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq. Science, 358:1622 (*co-first authors; #co-last and co-corresponding authors)

82. Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S (2017) Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell, 171:1368

83. Kuka M and Iannacone M (2017) Intestinal flossing keeps pathogens at bay. Developmental Cell, 43:383

84. Pirzgalska RM, Seixas E, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI (2017) Sympathetic associated macrophages clear norepinephrine and sustain obesity. Nature Medicine, 23:1309

85. Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G (2017) Microcirculation in mouse liver lobule: a Computational Fluid Dynamic model based on 3D reconstruction from in vivo microscopy. Journal of Biomechanics, 63:125

86. Jimenez de Oya N, De Giovanni M, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M (2017) Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens. EMBO Molecular Medicine, 9:1482

87. Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Science Immunology, 2:eaai8071

88. Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G. (2017) Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives 
viral persistence. Frontiers in Immunology, 8:811

89. Castiello MC, Pala F, Sereni L, Draghici E, Inverso D, Sauer AV, Schena F, Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M (2017) In vivo chronic stimulation unveils intrinsic autoreactive potential of Wiskott-Aldrich syndrome protein-deficient B cells. Frontiers in Immunology, 8:490

90. Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M (2017) Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology. Journal of Hepatology, 67:543

91. Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W (2017) CD8+ T cells orchestrate pDC–XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. Immunity, 46:205

92. Sammicheli S, Kuka M, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M (2016) Inflammatory monocytes hinder antiviral B cell responses. Science Immunology, 1:eaah6789

93. Iannacone M (2016) Platelet-mediated modulation of adaptive immunity. Seminars in Immunology, 28:555

94. Benechet AP, Ganzer L, Iannacone M (2017) Intravital microscopy analysis of hepatic T cell dynamics. Methods in Molecular Biology, 1514:49

95. Benechet AP, Iannacone M (2017) Determinants of hepatic effector CD8+ T cell dynamics. Journal of Hepatology, 66:228

96. Iannacone M, Chisari FV, Guidotti LG (2016) Protective and Pathogenic T Cell Responses to Virus Infections. Encyclopedia of Immunobiology, 4:318

97. Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G (2016) IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Molecular Medicine, 8:155

98. Iannacone M, Guidotti LG (2015) Mouse models of HBV pathogenesis. Cold Spring Harbor Perspectives in Medicine, 5:a021477

99. Inverso D, Iannacone M (2016) Spatiotemporal dynamics of effector CD8+ T cell responses within the liver. Journal of Leukocyte Biology, 99:51

100. Iannacone M, Guidotti LG (2016) HBV Immunopathogenesis. In Hepatitis B Virus in Human Diseases, Molecular and Translational Medicine – Book series, Springer, 4:79

101. Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M (2015) Immunosurveillance of the liver by intravascular effector CD8+ T cells. Cell, 161:486

102. Iannacone M, Guidotti LG (2015). Viral Pathogenesis. Current Opinion in Virology, 11:1 (invited section editor)

103. Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G (2015) A luminescent Poly(amidoamine)-Iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy. Inorganic Chemistry, 54:544

104. Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M (2014) PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Clinical Immunology, 156:98

105. Sironi L, Bouzin M, Inverso D, D’Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G (2014) In Vivo Flow Mapping in Complex Vessel Networks by Single Image Correlation. Scientific Reports, 4:7341

106. Iannacone M (2015) Hepatic effector CD8+ T cell dynamics. Cellular and Molecular Immunology, 12:269

107. Ilyinskii PO, Roy CJ, O’Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine, 32:2882

108. Kuka M, Iannacone M (2014) The role of lymph node sinus macrophages in host defense. Ann N Y Acad Sci, 1319:38

109. Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M (2013) Bisphosphonates target B cells to enhance humoral immune responses. Cell Reports, 5:323

110. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH (2013) Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions. Immunity, 39:496

111. Sitia G, Iannacone M, Guidotti LG (2013) Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. Journal of Hepatology, 59:1135

112. Guidotti LG, Iannacone M (2013) Effector CD8 T cell trafficking within the liver. Molecular Immunology, 55:94

113. Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, von Andrian UH (2012) Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes. Cell, 150:1249

114. Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG (2012) Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. PNAS, 109:E2165

115. Moseman EA*, Iannacone M*, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH (2012) B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity, 36:415 (*co-first authors)

116. Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P (2012) Follicular helper Natural Killer T cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+ T cells. Journal of Immunology, 188:3217

117. Chevrier N, Mertins P, Artyomov MN, Shalek AK, Garber M, Iannacone M, Ciaccio MF, Gat-Viks I, Eisenhaure TM, Clauser KR, Yosef N, Tonti E, Root DE, Beutler B, von Andrian UH, Jones RB, Park H, Carr SA, Regev A, Amit A, Hacohen N (2011) Systematic discovery of signaling components identifies new branches in viral-sensing pathways. Cell, 147:853

118. Sitia G*, Iannacone M*, Aiolfi R, Isogawa M, van Rooijen N, Scozzesi C, Bianchi ME, von Andrian UH, Chisari FV, Guidotti LG (2011) Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathogens, 7:e1002061 (*co-first authors)

119. Iannacone M, Moseman EA, Tonti E, Bosurgi L, Henrickson SE, Whelan S, Guidotti LG, von Andrian UH (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature, 465:1079

120. Iannacone M, Sitia G, Guidotti LG (2009) On the role of platelets in the pathogenesis of viral hepatitis. Journal of Hepatology, 51:593

121. Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG (2008) Platelets prevent IFN-ab-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. PNAS, 105:631

122. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson S, Shayakhmetov DM, van Rooijen N, Mempel T, Whelan S., von Andrian UH (2007) Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 450:110

123. Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG (2007) Antiplatelet Drug Therapy Moderates Immune-Mediated Liver Disease and Inhibits Viral Clearance in Mice Infected with a Replication-Deficient Adenovirus. Clinical and Vaccine Immunology, 14:1532

124. Nascimbene A, Iannacone M, Brando B, De Gasperi A (2007) Acute thrombocytopenia after liver transplant: Role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment. Journal of Hepatology, 47:651

125. Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG (2007) HBV pathogenesis in animal models: recent advances on the role of platelets. Journal of Hepatology, 46:719

126. Sitia G*, Iannacone M*, Muller S, Bianchi ME, Guidotti LG (2007) Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. Journal of Leukocyte Biology, 81:100 (*Co-first authors)

127. Iannacone M, Sitia G, Guidotti LG (2006) Pathogenetic and antiviral immune responses against Hepatitis B virus. Future Virology, 1:189

128. Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG (2005) Platelets mediate cytotoxic T lymphocytes-induced liver damage. Nature Medicine, 11:1167

129. Sitia G, Iannacone M, Chisari FV, Guidotti LG (2005) Pathogenesis of Hepatitis B Virus in Transgenic Mice. Models of viral hepatitis, Vol. 25. F. F. von Weizsacker, and M. E. Roggendorf, eds. Karger, Basel, Switzerland, p. 25

130. Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Muller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA (2004) HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Reports, 5:825

131. Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG (2004) MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. Journal of Clinical Investigation, 113:1158

132. Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P (2002) The disposal of dying cells in living tissues. Apoptosis, 7:153

133. Bondanza A, Manfredi AA, Zimmermann VS, Iannacone M, Tincani A, Balestrieri G, Sabbadini MG, Querini PR (2001) Anti-beta2 glycoprotein I antibodies cause inflammation and recruit dendritic cells in platelet clearance. Thrombosis and Haemostasis, 86: 1257

134. Mauvais-Jarvis, F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR (2002) Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation, 109:141

CURRENT FUNDING:

vEIColo (Fondazione Compagnia di San Paolo, Fondazione Cariplo, Fondazione CDP)
HEPB – Innovate
€40,000
2024
Iannacone (Principal Investigator)

Gilead Sciences
INVESTIGATE EFFECTS OF PD1-TARGETED IL2V IN A HUPD1-KI HBV-TRANSGENIC MICE ADOPTIVE CELL TRANSFER MODEL
€510,000
2024 – 2027
Iannacone (Principal Investigator)

Horizon Europe Framework Programme – Doctoral Network (101167421)
UNDERSTANDING FRAILTY TOWARDS A FUTURE OF HEALTY AGING
€259,437
2025 –2029
Iannacone (Partner)

European Research Council – Advanced Grant (101141363)
ACQUIRED ADAPTIVE IMMUNE CELL DYSFUNCTION AND RESTORATION IN CHRONIC HEPATITIS B
€2,500,000
2024 –2029
Iannacone (Principal Investigator)

Medical Research Council – Developmental Pathway Funding Scheme
DEVELOPING AN INFECTION-BLOCKING PAN-CORONAVIRUS VACCINE
£350,000
2024-2026
Iannacone (Co-Investigator)

European Research Council – Proof of Concept Grant (101138728)
SPIROCYCLIC CAMS AS NOVEL AND ULTRAPOTENT ANTI-HBV DRUGS
€150,000
2023 –2024
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – 5 per 1000 (22737)
ADVANCED IMMUNE GENE AND CELL THERAPIES FOR LIVER METASTASES
€678,172
Nov 2019 – Oct 2026
Iannacone (Group Leader)

VIR Biotechnology
TO CHARACTERIZE THE IN VIVO EFFECT OF HUMAN MONOCLONAL ANTIBODIES AGAINST HBV
€529,125
2023-2025
Iannacone (Principal Investigator)

Italian Ministry for University and Research (Project no. PE00000007, INF-ACT)
EXTENDED PARTNERSHIP INITIATIVE ON EMERGING INFECTIOUS DISEASES
€450,000
2023-2025
Iannacone (Group Leader)

Italian Ministry for University and Research (PRIN 2022FMESXL)
MECHANISMS UNDERLYING DYSFUNCTIONAL CD8+ T CELL RESPONSES IN CHRONIC HEPATITIS B
€211,480
2023-2025
Iannacone (Coordinator)

BlueJay Therapeutics
TO EVALUATE THE THERAPEUTIC POTENTIAL OF THE PD-1/IL-21 ANTIBODY CYTOKINE FUSION
€21,000
2024
Iannacone (Principal Investigator)

SELECTED COMPLETED FUNDING:

European Research Council – Starting Grant (281648)
IN VIVO DYNAMICS OF ANTIBODY RESPONSES TO LYMPH-BORNE VIRUSES
€1,934,200
Mar 2012 – Jun 2017
Iannacone (Principal Investigator)

European Research Council – Proof of Concept Grant (957502)
IL-2 GENE THERAPY FOR CHRONIC HEPATITIS B VIRUS INFECTION
€150,000
Jul 2020 – Jun 2022
Iannacone (Principal Investigator)

European Research Council – Consolidator Grant (725038)
FUNCTIONAL BIOLOGY OF HEPATIC CD8+ T CELLS
€2,390,000
Jul 2017 – Dec 2023
Iannacone (Principal Investigator)

Armenise-Harvard Foundation – Career Development Award
IN VIVO IMAGING OF ANTIVIRAL IMMUNE RESPONSES
$1,000,000
Nov 2010 – Oct 2015
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – Individual Grant MFAG (15350)
THE ROLE OF ANTIGENIC STIMULATION IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA
€225,000
Jan 2015 – Dec 2017
Iannacone (Principal Investigator)

AIRC (Italian Association for Cancer Research) – Program Project (9965)
HARNESSING TUMOUR CELL/MICROENVIRONMENT CROSS TALK TO TREAT MATURE B-CELL TUMOURS
€420,000
Nov 2010 – Oct 2015
Iannacone (Group Leader)

AIRC (Italian Association for Cancer Research) – Investigator Grant (19891)
SPATIOTEMPORAL DYNAMICS OF CD8+ T CELLS WITHIN LIVER TUMORS
€1,062,000
Jan 2018 – Dec 2023
Iannacone (Principal Investigator)

Italian Ministry of Health – Giovani Ricercatori (GR-2011-02347925)
DISSECTING HBV PATHOGENESIS THROUGH THE USE OF INTRAVITAL MICROSCOPY
€342,000
Nov 2014 – Nov 2017
Iannacone (Principal Investigator)

Italian Ministry of Health – Ricerca Finalizzata (RF-2018-12365801)
DETERMINANTS OF INTRAHEPATIC CD8+ T CELL PRIMING
€450,000
Jul 2020 – Jun 2023
Iannacone (Principal Investigator)

Fondazione Regionale per la Ricerca Biomedica (2015-0010)
SINGLE-CELL ANALYSES OF LYMPHOCYTES THAT INFILTRATE AUTOIMMUNITY SITES: DISSECTING IMMUNOLOGICAL MECHANISMS OF RHEUMATOID ARTHRITIS
€630,000
Mar 2017 – Feb 2020
Iannacone (Co-Principal Investigator)

Italian Ministry of Health – Bando COVID-19 (COVID-2020-12371617)
CLINICAL AND BIOLOGICAL CHARACTERIZATION OF PATIENTS WITH COVID-19
€150,000
Sep 2020 – Aug 2021
Iannacone (Group Leader)

Takis Biotech
THE CAPACITY OF VACCINES AND SINGLE-CHAIN ANTIBODIES TO PREVENT SARS-COV-2 INFECTION
€135,000
2021-2022
Iannacone (Principal Investigator)

Gilead Sciences
THE CAPACITY OF IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+ T CELLS
€631,875
2019-2022
Iannacone (Principal Investigator)

Asher Biotherapeutics
TO DETERMINE THE CAPACITY OF CD8-TARGETED IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+ T CELLS
€447,550
2021-2023
Iannacone (Principal Investigator)